Hacking State

13 - Steve Hsu: Polygenic Embryo Selection, Improving LLMs, & Getting Nearly Cancelled

Steve Hsu is Professor of Theoretical Physics at Michigan State University, as well as the founder of Genomic Prediction and SuperFocus AI; he also hosts the Manifold podcast, and the Information Processing blog.
Steve and I speak about polygenic risk scoring and embryo selection, using AI to predict phenotype from genotype, in-vitro fertilization (IVF), egg freezing, eugenic public policy, addressing Christians' and right-wing traditionalists' concerns over reproductive technology, SuperFocus AI's plan to eliminate hallucination in large language models (LLMs) by separating memory from inference, introspection for LLM error correction, and surviving the failed cancellation attempt at MSU.
 
Steve Hsu:
On X: https://twitter.com/hsu_steve
Personal Site: https://infoproc.blogspot.com/
Manifold podcast: https://www.manifold1.com/
Genomic Prediction: https://www.lifeview.com/
SuperFocus AI: https://superfocus.ai/
 
If you enjoyed this interview, please leave a review on Spotify/iTunes. Support Hacking State: https://hackingstate.substack.com/subscribe
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Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml

12 - Garrett Dailey: Designing Business Around Philosophy

Garrett Dailey is the founder of Aion Enterprises, a business philosophy and design firm. We speak about the meaning of Aion, building a business around philosophy, individuation, the Candy Cane model of reality, and the importance of aesthetics for catalyzing people with a compelling vision of the future.
“Any sufficiently complex thought is philosophy.”
Aion:
https://www.aion.enterprises/ https://twitter.com/AionEnterprises
Garrett Dailey:
https://garrettdailey.substack.com/ https://twitter.com/Liber_Rex
 
If you enjoyed this interview, please leave a review on Spotify/iTunes.
Support Hacking State: https://hackingstate.substack.com/subscribe
Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076
Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml

11 - Disgraced Propagandist: The World of Dissident Marketing

Disgraced Propagandist (Isaac Simpson) is the founder of WILL, a dissident marketing agency, and The Carousel Substack and podcast. We speak about how WILL does dissident marketing for a cohort of new natural “wholesome” brands, the marketing industry as the canary in the coal mine for workplaces becoming Longhouses, the power of branding, the meaning of The Carousel metaphor, nostalgia, the “hype dad” archetype, his literary influences, and NEVER APOLOGIZE!
 
WILL, the agency: https://willtheagency.com/
On X: https://x.com/WILLtheagency
 
The Carousel:
https://thecarousel.substack.com/
 
Disgraced Propagandist: 
On X: https://x.com/DisgracedProp
Site: https://isaacsimpson.com/
 
 
If you enjoyed this interview, please leave a review on Spotify/iTunes.
Support Hacking State: https://hackingstate.substack.com/subscribe
Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076
Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml
 

10 - Razib Khan: Genetic Time Traveling

Razib Khan is a population geneticist, has a popular Substack on genetics and history, and is a co-founder of GenRAIT.
We speak about his role in the scientific ecosystem, the effect of the computing revolution on ancient genetics and genomics, why he’s most interested in Eurasian steppe populations, how ancient DNA has shed light on theories in archeology and philology, the effects of delayed fertility on genetic quality of offspring, prenatal genetic screening and gene editing, selection effects of modern environments, his startup, GenRait, and his antics on Twitter/X.
 
 
Website: https://www.razib.com/
Twitter/X: https://twitter.com/razibkhan
GenRait: https://www.genrait.com/

9 - Hannah Frankman: On the Education of Rebels

Hannah Frankman is the founder of Rebel Educator, an all-inclusive resource hub for parents, teachers, and entrepreneurs. We discuss her experiences in educational reform and alternative paths to education, Montessori education philosophy, her involvement in the education space, and the launch of Rebel Educator. We also cover criticisms of the educational system and popular alternatives, homeschooling, the potential benefits of accelerated and decelerated learning, the need for more localized, private, and independent schools, and the importance of values in education.
 
Hannah Frankman
Website: http://hannahfrankman.com/
Twitter: https://twitter.com/HannahFrankman
Podcast: https://www.youtube.com/@thehannahfrankmanpodcast
 
Rebel Educator: https://rebeleducator.co/
Twitter/X: https://twitter.com/rebelEducator
 
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Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076  Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml 

8 - Bo Winegard: Aporias of Human Nature

Bo Winegard on life after cancellation, why we should talk about group differences in intelligence, Aporia - a new magazine courting heterodox social science and philosophy, victimhood rhetoric, the tedious relationship of truth to justice, anonymity vs. identity, are we at peak wokeness?, noble lies, epistemic accelerationism, limits to academic discourse in public, and his proposal for a Republic; if you can keep it.
 
Bo Winegard is a Social Psychologist and Executive Editor of Aporia.
Bo Winegard on Twitter:
https://twitter.com/EPoe187
Aporia Magazine:
https://www.aporiamagazine.com/
 
Support Hacking State: https://hackingstate.substack.com/subscribe
Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076
Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml

7 - Mark Wilcox: 21e8 and Computational Data Markets

Mark Wilcox on 21e8, his information architecture company, computational data markets, why compute is money, Bitcoin’s role in all this, price discovery via compute, how AI is destroying people’s belief in the computer, deleveraging from the U.S. dollar, decision theory, the curse of dimensionality, and moving back to base primitives.
 
“The problem to solve is how much compute it takes to generate value.” -  Mark Wilcox
 
Mark Wilcox on Twitter: https://twitter.com/mwilcox
21e8 (company):
Twitter - https://twitter.com/21e8ltd
N.Z. - https://21e8.nz/
U.S. - https://21e8.com/
 
Support Hacking State: https://hackingstate.substack.com/subscribe
Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076
Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml

6 - Jason Snyder: Growing Doomer Optimism

I speak with Doomer Optimist cofounder and faculty in the Department of Sustainable Development at Appalachian State University, Jason Snyder, about finding the others, using the internet to encourage localism, Balaji Srinivasan’s The Network State, homesteading, the value of embodied work, regenerative agriculture, resource independence, and our disagreement on degrowth.
 
Doomer Optimism is an eclectic metamodern movement building a template for post-collapse.
 
“I don’t think the industrial food system as its currently composed is sustainable.” - Jason Snyder
 
Jason Snyder on Twitter: https://twitter.com/cognazor
 
About Doomer Optimism:
Twitter: https://twitter.com/DoomerOptimism 
Website: https://www.doomeroptimism.com/ 
 
Support Hacking State: https://hackingstate.substack.com/subscribe
Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076
Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml

5 -Jonah Davids: Mental Health is Unwell

Jonah Davids' new Substack, Mental Disorder, explores the science and politics of mental health from a data-driven perspective. Jonah is also Communications Director at the Center for the Study of Partisanship and Ideology.
We spoke about why being a psychologist has no noticeable effect on the efficaciousness of talk therapy, the lack of evidence in mental health treatment, how CBT became the gold standard and why its not more effective than other therapies, the case for fixing your material conditions to improve mental health, lowering barriers to entry for mental health workers, how mental health professionals are less mentally healthy than the general population, and more...
Jonah on Twitter:
https://twitter.com/jonahdavids1
Jonah on Substack:
https://mentaldisorder.substack.com/
 
Related writings:
 On CBT:
https://mentaldisorder.substack.com/p/is-cbt-superior-jonah-davids
On the sadness of psychologists: https://www.mentaldisorder.ca/p/how-sad-are-psychologists 
Whether loneliness should be considered a public health problem: https://www.mentaldisorder.ca/p/loneliness-public-health-problem-jonah-davids
 
Support Hacking State: https://hackingstate.substack.com/subscribe
Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076
Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml
 

4 - Cody Moser: The Science of Innovation, Core-Periphery Networks, Internet Polarization

Cody Moser is a PhD student in the Department of Cognitive and Information Sciences at University of California, Merced. His work focuses primarily on the evolution of human behavior and human institutions.
We spoke about his work generating formal network models with agent-based modeling, the life history of organizations, core-periphery dynamics and why "loser" nodes are necessary for network innovation, the tension between explore-exploit tradeoffs in organizations, generative adaptive systems, path dependency and organizational longevity, why we want hyper-hyper polarization on the internet, and more...
"Innovators come from the outside." - Cody Moser
Cody Moser's blog: https://culturologies.co/
His Twitter: https://twitter.com/LTF_01
UC Merced bio: https://cogsci.ucmerced.edu/content/cody-moser
Paper on core-periphery networks in innovation: https://culturologies.co/files/coreperiphery.pdf
All Intelligence is Collective Intelligence: https://www.neuralpress.org/_files/ugd/1dd990_f5fc8a4eef6142b48e387daa9c4454e7.pdf  
The Ties That Bind Us: https://culturologies.co/files/HungarianConservative.pdf
Internet polarization: https://culturologies.substack.com/p/internet-polarization-reform-and?nthPub
 
Support Hacking State: https://hackingstate.substack.com/subscribe
Listen on:
Youtube: https://www.youtube.com/@alexmurshak
Apple: https://podcasts.apple.com/us/podcast/hacking-state/id1689677076
Spotify: https://open.spotify.com/show/1XB9XYULrAY4dp0qIJVvCg
RSS: https://feed.podbean.com/hackingstate/feed.xml